There is a trait which must be coupled to self-actualization: self-*realization*. It is not enough to see what one’s full potential is – one must also find an effective means of expression and self-transformation to see that potential accomplished. This is very hard, and is probably necessary for an actualized state to remain stable.
…Because otherwise the world will pwn you 🙂
Social networking, for instance, is a good example of an analogue to Fisherian runaway: the desire for the trait and the trait itself coevolve, until everyone has social because everyone wants social, rather than because it adds any functionality, value, or relevance. I suspect most social movements, and in fact traditions, are like this.
Some bacteria evolve resistance to antibiotics via enzymes which break components of the antibiotic down (others just evolve completely different strategies to perform their biological functions, which render the antibiotics irrelevant). Trivial idea: subvert this by administering adjuvants which prevent these enzymes from working!
The efficient market hypothesis.