Author Archives: Michael

Maybe killing malignant cells isn't the answer.

Unless the specificity of an anticancer drug approaches 100%, anything that kills off cancer cells is going to kill off some normal ones as well. This means side effects, often quite nasty.

But what if, instead of killing off cancerous cells, we just shut down their invasive potential?

I’ve been reading up on what differentiates noninvasive cancer cells – carcinoma in situ – against invasive cells. The literature on this has been surprisingly sparse, so either I’m not looking for the right things (quite possible), or this is a very understudied approach. The papers I’ve read have identified a few gene loci and a protein called Twist, but that is as far as I can take my search, lacking the resources to experimentally pursue such lines of study.

My point is this: carcinoma in situ is harmless except in its ability to become invasive cancer. Most of the proteins that seem to cause aberrant behavior in cancer cells seem those that are present during embryonic development (which makes sense in a way, since embryonic development is high-rate controlled, regulated division, whereas carcinogenesis is high-rate uncontrolled, unregulated division), but these proteins are all but absent in adults.

So rather than attempting to kill off the cancer cells, why not attempt to remove their ability to invade (and thus metastasize, destroy tissue, and cause other problems)? Even if the treatment were nonspecific, side effects should be far milder than the “killer” drugs, since normal cells are not known to depend on the function of the identified proteins. And unlike drugs that kill cells, there is little selective pressure against the treatment.

I see so many solutions to this problem. How I wish I could take part…

AnandTech doesn't know me very well.

Heh… Straight from Anandtech:

http://images.anandtech.com/reviews/video/NVIDIA/Badaboom/cuda2.jpg

“The performance advancements were incredible, NVIDIA was promising upwards of 100x gains over the fastest workstation CPUs. Unfortunately we couldn’t get too terribly excited as most of these applications were far beyond the reach of the typical desktop user. Medical imaging and scientific analysis benefitted tremendously from GPU acceleration, but it’s rare that a gamer with a $400 GPU is going to be searching for oil deposits in his/her spare time on the same machine.”

I don’t know; the gains on matrix multiplication, sequence matching, and the FFT are quite appealing to me… but so is being able to run new games quickly 🙂

Unfortunately, I’m pretty sure these gains are going to require use of a special API to realize. So until Matlab integrates CUDA, they may be a ways off.

And a depressing thought…

As of today, I’m 24 (this blog is an hour behind my timezone). What have I done with my life so far? The academic accomplishments are all great, but the knowledge means nothing unless I can put it to use in a meaningful way. My current research just isn’t providing me with the significance I think I need out of pursuing a big problem. It doesn’t seem like there are any big problems in the subfield I landed in to go after, either, unless I plan on going into search and competing with Google some time down the road.

Using computers to diagnose cancer? I’d still rather be using them to treat it.

A thought on depressions…

An economic boom is a time when the value consumed exceeds the value generated within an economy. In other words, there is money floating around that does not actually have a grounding in any valuable economic activity but can be used to consume value all the same (remember, money is not actually value; it’s an imprecise representation of it). The bust that invariably follows such an era is the elimination of the “negative value” that has accumulated from such a boom and a return to economic equilibrium, where money actually begins to represent value again. If I can be so bold as to rip off one of the laws of thermodynamics for my own purposes:

The overall change in the energy of a system is the change in heating – the change in work. In economics, the formulation is even simpler: profit = revenue – cost.

They are actually saying the same thing using different terms. In fact, if you used energy as a currency, these would be exactly the same law.

This time around, many people were given loans that they could not repay. These loans appear to have been used primarily to finance house purchases, which caused demand to rise and the price of a house to artificially increase. It was, of course, the sort of fake money I had just mentioned, untied to any real value because nothing significantly changed in overall productivity to match the increased consumption.

The economy, unlike the universe, is an open system. Value can be both added and removed. No significant value was added to the system, so “value revenue” was 0. The money used to purchase houses destroyed value, so “value cost” was positive. Thus, value was lost.

Because money is an imprecise measure of value, it took a while for people to notice, and thus everything appeared to be going really well.

Until it finally caught up, of course. The fall in house prices that followed was an act of balance. The pathological money was eliminated from the economy as house prices fell, thus it became tied to the actual value of the houses again. (The other solution that would have resulted in equilibrium would have been massive amounts of inflation, so this is actually preferable).

The reason why this is a disaster rippling throughout the economy is mere reliance on this fake money by both the lenders (who collected interest on it) and the borrowers (who “leveraged” it). The interest they collected was fake value too, of course. And then they invested that into other assets. And that was also fake.

When the bubble burst, this complex web of interdependencies, all built with valueless money, fell apart. That’s my take on it, anyway.

So for those who consider my frustration with inauthenticity unwarranted, consider what effect it has had on your economy. They spring from the same cause.

Papers and Inauthenticity

Just once, I’d like to write a paper that communicated its results clearly, without all sorts of excess fluff. Literally every time I write a paper, the nonsense I need to put into it thanks to the way the system is arranged both depresses and infuriates me. Surrounding a pure idea with meaningless words is like using mud to frost a delicious cake.

But then it would be one or two pages long, would have very few references (why people think it’s a good practice to acknowledge papers you’ve never even read or used, I’ll never know), and would be immediately rejected by peer reviewers. (Thanks, oh faithful Gatekeepers of Truth, for making it impossible to effectively communicate ideas). The skill most people call technical writing seems to be primarily in convincing people that what you’re writing is not actually filler. I think I’ve become very good at it by now because I’m getting a lot of things published by this point, but it’s not that the ideas are any different from before – I just frosted them with more mud.

Getting a Ph. D. is exhibiting mastery of this skill, by writing 150+ pages of material to present the same one page of results that I’m currently devoting 10 pages to this time around. I actually did that first, but copying and pasting from my dissertation is considered “autoplagiarism” (Plagiarism = taking credit for the ideas of another. Therefore, autoplagiarism = taking credit for your own ideas), so I can’t even use the material I’ve previously written on the same topic.

The long list of publications people show off in order to cudgel their way into academic positions tends to be composed of at most 3 or 4 ideas, rehashed in different ways, with minor variations on the details, but very little true originality. And it works because no one has the time to read the majority of an applicant’s papers! The best people have managed to do is include an “acceptance ratio”, or measure of how selective the conferences and journals submitted to were, as if peer endorsement guarantees that the idea within is good.

It’s all so fake, just like society in general. And when true authenticity occasionally rears its head (as it must, because civilization still exists), it’s immediately bludgeoned and violently suppressed.

I must say, an agrarian lifestyle seems more appealing with each passing day. Nature alone rewards honesty. I don’t know how much more of this I can take.

Autumn

It is that time again
when I revel in nature
unfolding its splendor
all around me.

The glory of reds and yellows
advancing on the green, and set
against the blue and white,
like fluffed celestial pillows.

I belong to it,
and it to me,
a transcendent bond that asks
only that I survive.

I revel from behind a window,
while politicians dance,
and the market fails
and I am trapped.

Thanks to the trustees!

Now that it’s time to develop workable strategies to institute a university, the trustees of the foundation, who were selected primarily on the basis of their ideas, are showing their worth. The strategy we’re developing is a masterwork. This is by far the most competent group I’ve ever seen – it’s the first time I’ve actually seen “synergy” in action. Thanks, everyone!

Four INTJs, taking on the world for something they believe is Right. The world doesn’t stand a chance 🙂

An observation on market volatility in times of panic…

When there’s a general spirit of panic, the markets tend to fall by punctuated equilibrium. They’ll remain steady over months and then suddenly drop a great deal over a short period of time without warning.

It happened during the depression, and it’s also happening now. The decline has been fairly steady, but there have been days recently where the DJIA dropped 400+ points.

Still nothing on the scale of Black Tuesday. It would have to lose 20% of its value in a single day to exceed that.